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O C 40mg

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Product Description

Oxycodone is an opioid analgesic medication synthesized from thebaine. It was developed in 1916 in Germany, as one of several new semi-synthetic opioids with several benefits over the older traditional opiates and opioids; morphine, diacetylmorphine(heroin) and codeine. It was introduced to the pharmaceutical market as Eukodal or Eucodal and Dinarkon. Its chemical name is derived from codeine - the chemical structures are very similar, differing only in that the hydroxyl group of codeine has been oxidized to a carbonyl group (as in ketones), hence the -one suffix, the 7,8-dihydro-feature (codeine has a double-bond between those two carbons), and the hydroxyl group at carbon-14 (codeine has just a hydrogen in its place), hence oxycodone. In the United States, oxycodone is a Schedule II controlled substance both as a single agent and in combination with products containing paracetamol (aka acetaminophen), ibuprofen or aspirin. Oxycodone is commercially made from thebaine, an opiate alkaloid and minor component of opium.

Side effects

The most commonly reported effects include constipation, euphoria, fatigue, dizziness, nausea, lightheadedness, headache, dry mouth, pruritus, and diaphoresis. It has also claimed to cause dimness in vision due to miosis. Some patients have also experienced loss of appetite, nervousness, anxiety, abdominal pain, diarrhea, dyspnea, and hiccups, although these symptoms appear in less than 5% of patients taking oxycodone. Rarely, the drug can cause impotence, enlarged prostate gland, and decreased testosterone secretion.

In high doses, overdoses, or in patients not tolerant to opiates, oxycodone can cause shallow breathing, bradycardia, cold, clammy skin, apnea, hypotension, pupil constriction, circulatory collapse, respiratory arrest, and death.

Withdrawal related side effects
There is a high risk of experiencing severe withdrawal symptoms if a patient discontinues oxycodone abruptly. Therefore therapy should be gradually discontinued rather than abruptly discontinued. Drug abusers are at even higher risk of severe withdrawal symptoms as they tend to use higher than prescribed doses. Withdrawal symptoms are also likely in neonates born to mothers who have been taking oxycodone or other opiate based pain killers during their pregnancy. The symptoms of oxycodone withdrawal are the same as for other opiate based pain killers and may include the following symptoms.

  1. Anxiety
  2. Nausea
  3. Insomnia
  4. Muscle pain
  5. Fevers
  6. Flu like symptoms


Dosage and administration
Oxycodone can be administered orally, intranasally, via intravenous/intramuscular/subcutaneous injection, by vapourizing/smoking or rectally. The bioavailability of oral administration averages 60-87%, with rectal administration yielding the same results. Injecting oxycodone will result in a stronger effect and quicker onset.

Percocet tablets, oxycodone with acetaminophen (paracetamol), are routinely prescribed for post-operative pain control. Tablets are available with 2.5, 5, 7.5, 10 or 15 mg of oxycodone and varying amounts of acetaminophen. Oxycodone is also used in treatment of moderate to severe chronic pain. Both immediate-release and sustained-release oxycodone are now available (OxyNorm and OxyContin in the UK). There are no comparative trials showing that oxycodone is more effective than any other opioid. In palliative care, morphine remains the gold standard. However, it can be useful as an alternative opioid if a patient has troublesome adverse effects with morphine.

OxyNorm is available in 5, 10, and 20 mg capsules and tablets; also as a 1 mg/1 ml liquid in 250 ml bottles and as a 10 mg/1 ml concentrated liquid in 100 ml bottles. Available in Europe and other areas outside the United States, Proladone suppositories contain 15 mg of oxycodone pectinate and other suppository strengths under this and other trade names are less frequently encountered. Injectable oxycodone hydrochloride or tartrate is available in ampoules and multi-dose vials in many European countries and to a lesser extent various places in the Pacific Rim. For this purpose, the most common trade names are Eukodol and Eucodol.

Roxicodone is a generically made oxycodone product designed to have an immediate release effect for rapid pain relief, and is available in 5 (white), 15 (green), and 30 (light blue) mg tablets. Generic versions of Roxicodone may differ in color from the brand name tablets.

OxyContin is available in 10 mg (white), 15 mg (black), 20 mg (pink), 30 mg (brown), 40 mg (yellow), 60 mg (red), and 80 mg (green) in the U.S. and Canada, and 160 mg (blue) in Canada only. Because of its sustained-release mechanism, the medication is typically effective for eight to twelve hours. The 160 mg tablets were removed from sale due to problems with overdose, but have been re-introduced for limited use under strict medical supervision. On October 18, 2006, the FDA gave approval for four new dosage strengths, to wit, 15, 30, 45, and 60 mg. After removing the colored outer coating, which weighs 8 mg (approx.), the mass of a standard 80 mg OxyContin tablet is 256 mg (approx.): 80 mg of oxycodone hydrochloride and 176 mg (approx.) of innactive material, making the formulation 31% pure (approx.) by weight.

Generic OxyContin was introduced in 2005 (80 mg) and 2006 (10, 20, and 40 mg). However, because of numerous law suits related to the addictive and abuse potential of the medicine, generic manufacture (alternatively reported as except by Dava) ceased on December 31, 2007. Oxycodone/APAP pills are still avaliable through prescription only.

The controlled (sustained)-release preparations are essential to provide a background plasma level of analgesia in anyone with persistent pain. The immediate release preparations are useful for breakthrough pain, which can break through the controlled-release baseline medication. There are no trials to show that one manufacturer produces a more effective oxycodone product than any other.

Abuse
Oxycodone is a drug subject to abuse. The drug is included in the sections for the most strongly controlled substances that have a commonly accepted medical use, including the German Betäubungsmittelgesetz III (narcotics law), the Swiss law of the same title, UK Misuse of Drugs Act (Class A), Canadian Controlled Drugs and Substances Act (CDSA), Dutch Opium Law (List 1), Austrian Suchtmittelgesetz (Addictives Act), and others. It is also subject to international treaties controlling psychoactive drugs subject to abuse or dependence.

The abuse of OxyContin and its generic equivalents has greatly increased since the introduction of the sustained-release form of oxycodone. Illegal distribution of OxyContin occurs through pharmacy diversion, physicians, doctor shopping, faked prescriptions, and robbery, all of which divert the pharmaceutical onto the illicit market. In Australia alone during 1999 and 2000, more than 260,000 prescriptions for narcotics and codeine-based medications were written to almost 9,000 known abusers at a cost of more than $750,000 AUD (approx $602,000 US). Purdue Pharma and its top executives pleaded guilty to felony charges that they misbranded and misled physicians and the public by claiming OxyContin was less likely to be abused, less addictive, and less likely to cause withdrawal symptoms than other opiate drugs. The company also paid millions in fines relating to aggressive off-label marketing practices in several states.

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Product Reviews

  1. Unless you have been

    Posted by Zezo on 15th Feb 2016

    Unless you have been addicted to Oxy, you caonnt know just how powerful of a drug addiction can come from the use of this painkiller. Like this poor soul, I was prescribed Oxy for legitimate back condition. At first it was a Godsend, I finally for the first time in years was able to live relatively pain free. But that drug does more then alleviate physical pain it produces an amazingly good feeling, it's like nothing I ever felt and for awhile it worked so well too well as a matter of fact. I ended up gradually becoming addicted to Oxy. I found my weeks worth of pills gone in just a few days and then I'd be scrambling to try and buy off the street at insane prices. Slowly I decended into addictive hell. I tried cold turkey a couple times and made it through the WORST withdrawls ever but a month in the MENTAL part the hardest part of detoxing caught up with me and I relapsed. I had always suffered from depression and anxiety and after successfully numbing those feelings for so long, I was not prepared for the onslaught of severe depression and anxiety that followed my detox. At one point I wanted to slam my van into a pole. The misery I felt post detox was unrelenting and unending. I went back to using oxy once again at first I managed to keep it at my prescribed dose but sure enough that all changed and I found myself just as addicted as before. Back to square one. I finally sought treatment. I was petrified to do so before. I have two young children and was convinced that seeking help might jeopardize my custody of them. The idea of there even being the faintest chance that they might be taken from me kept me from seeking help for a long long time. It's a crying shame that mothers have to be scared to get treatment for fear that they will have their kids taken away. Of course I can see some cases where the child should be taken (the mother is so strung out that she is unable to care for her kids) but that wasn't the case with me. In fact, nobody knew I was an addict. I take excellent care of my kids and considered myself to be a high functioning addict. But an addict nonetheless. But unfortunately the medical community tends to paint us all with one black brush and we are looked down upon. She's a pill abuser she caonnt possibly be able to take care of her kids, lets take them is the mentality of these people who are supposed to be helping addicts. But I took a chance after finding a suboxone doctor who I believed I could trust. My faith in him proved to be correct. I have been on suboxone for a few months and even though I have had some slip ups, (the suboxone does NOTHING for pain and sometimes I can't stand the pain anymore and end up taking one or two pills I know I'm not supposed to but hey, I've gone from taking 100+mgs of oxy a day to just 40-60 mgs the odd time when I really need it. My doctor still frowns when I pee dirty but remarkably, seems understanding when I explain WHY I mess up from time to time. I have heard stories of people being immediately dismissed from a methadone/suboxone program for ONE slip. That is incredibly ridiculous. So cancel the patient and in essence send them back into full blown addiction again over one mishap. Unfair and irresponsible on the providers part in my opinion. So although I am trying to get my life together with the help of suboxone, I still battle the pain that was the original reason why I was ever on oxy to begin with. It really sucks. On one hand I have severe pain that truly warrants pain relief but on the other I know I caonnt take the meds that being me relief like I'm supposed to so I'm stuck taking something to keep my addiction at bay but gives me zero pain relief. That's why I occasionally slip. I don't think I should be made to suffer in pain and this is what I've found works for me. Taking my suboxone regularly and when I really need it I take one or two pills. It's better then the alternative taking 100+ mgs a day of oxy, risking overdose and wasting money on street bought pills. If I had my time back I would have RUN when offered oxy for pain relief. If I had only known then the severely addictive nature of oxy and that the next two years of my life would be consumed by the drug I would have rather suffered the physical pain then endure the heartbreak of becoming an addict and all the crazyness that comes with that. Opiates can be both a life saver and life taker. There is a thin line and once you've crossed the line into addiction from dependence, by the time you realize you have a problem, your in too deep to just stop and your life as you knew it is over. I have a lot of regrets tied to my oxy addiction. A lot of if only's and a lot of why me? but in the end it has to be me who takes charge and one day I hope to be medication free. I'm a long ways from that day but I'm never giving up. Sadly our numbers are dismal. Rare is the opiate addict that can get clean and STAY clean. Opiates screw with your brain and I don't think after addiction to oxy etc that your ever going to be the same again. Staying clean is very hard but yes it is do-able. There are many who taper successfully from oxy, sub, methadone etc but more times then not they relapse. It's just such a powerful addiction that alters your mind and your thinking forever. Still, I hold out hope that one day I'll be able to manage my pain by other non-narcotic means and that I will be able to get off suboxone when I'm ready. My heart goes out to all addicts. We never asked for this. God knows we've suffered tremendously from being addicts and the reality is a lot of people will continue to die as a result of their addiction. Unless the stigma of being an addict is addressed and people, mothers in particular, can seek help without fear of being labelled a bad mom by CPS..addicts will continue to be stuck in addiction for fear of being punished if they seek help by having their kids taken away right down to being looked down upon my the medical community. There is little sympathy for addicts in the medical community. For people who are supposed to be trained in such areas, they are sadly ignorant of the reality of addiction. Instead of crucifying addicts, they need to be more open to helping addicts. It saddened me to see Hank lose his job. Is it not the law that companies need to help employees suffering from addictions to get into recovery? Firing him was not the answer and shows just how ignorant in general the public is about addiction. This man should have gotten offered help. Sub is incredibly expensive and if the company could have helped him by paying for it then that would have been the right thing to do. Firing him was not.